APPLICATIONS
MIPQs Sensors for Chemical Threat Agents (CTAs) and Organophosphates
Organophosphates (OP) are the basis of many insecticides, herbicides and nerve gases. OP include many CTAs, notably Tabun (GA), Sarin (GB), Soman (GD), Cyclosarin (GF), and so on. These neurological poisons are still ubiquitiusly used on agricultual crops and for mosquito control, and are widely used as simulants for CTAs .
MIPQs sensors for detection of organic phosphates as simulants of CTAs
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Specific to target analyte and short response time (30min)
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Potentially applicable to both CTAs and bio-threat agents (BTA)
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Wide detection range of various organophosphates
Detection Range (ppm)
Parathion ethyl
Paraxon ethyl
Parathion methyl
2.6 - 260
2.8 - 280
2.9 - 290
Normalized
MIPQs Sensors for CTA simulants using QCM
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Imprinted sensors have higher responses than non-imprinted ones to the target analyte - methyl parthion methyl (MP)
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LOD: 17.9 ppb of MP
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Highly selective to the target MP over typical interfering analytes, including dichlorophos (DCRP), diethylphosphoramidate (DEPA), 2,4,6-tricchlorophenoxyacetic acid (TCPAA), and terephthalic acid sodium salt (TANa)
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Good repeatability
Cycles
Fig 1. Selectivity and Repeatability of MIPQS sensors for CTA stimulants using QCM
MIP Coated
MP Conc. Spiked
Found by MIP
Sample No.
Conc. (nM)
Spiking test on cos lettuce with the MIPQS sensor
The moleccularly impinted sensor is robust in real sample analysis with good recovery (95 – 105%) and RSD value (1.52 – 3.80 %)
Fig.2 QCM Chip before and after MIP coating
Fig. 3 Mp concentration in real vegetable cos lettuce samples with spiked MP using the prepared MIP sensor
MIPQS Sensors for Biological threat agents (BTAs)
BTAs not only pose threats through bioterrorism and bio warfare, they are also a great hazard to safety by contamination of food or water. In 2001, letters containing anthrax spores were mailed to several news media offices, killing five people and infecting 17 others in USA. Early warning of possible exposure to BTAs is very important and urgently need.
MIPQS sensors for BTA simulants
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Sensor surface was porous for the transportation of large biomolecules •
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Good selectivity towards target analyte, i.e. concanavalin A (Con A) which triggers autophagic cell death, as protein-based BTA simulant, over structurally similar analytes (abbreviations: BSA – bovine serum albumin; Hb – haemoglobin; HSA – human serum albumin) •
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Strong inter-molecular interactions between target analytes and imprinted cavities
Fig. 4 Selectivity of MIPQs sensors for BTA simulant with (B) and (C) SEM micrographs at magnifications of 15,000 and 60,000
MIPQS Sensors Heavy Metals Testing
The MIPs Sensor is a portable device for heavy metals testing for drinking water, environmental and industrial water supplies. It uses an extremely sensitive measurement technique to determine the toxicity levels of heavy metal. The MIPS3001 SENSOR requires no special skills or knowledge of chemistry to operate, enabling field testing to be done within 10 minutes, eliminating or significantly reducing test expenditures, complexity and waiting time experienced in traditional heavy metals water testing. Powered by piezoelectric sensing, it is a breakthrough in streamlining the water analysis and reporting processes. The MIPS3001 is designed for use with all MIPS sensors and test kits.